Eunice Laurent, Ph.D.

Professor of Biology

Science Department
Valencia College, Osceola, FL


Education

B.A., Biological Sciences, DePauw University, Greencastle, IN, 1993
Ph.D., Molecular Biology, University of Texas Health Science Center, Houston, TX, 2001
FIRST Postdoctoral Fellow, Emory University School of Medicine, Department of Pathology and Laboratory Medicine, 2003-2006

Research Statement

The NADPH oxidase 1 (Nox1) messenger RNA is expressed predominantly in colon epithelial cells as well as in colon carcinoma cell lines (Suh et al, 1999; Cheng et al, 2001). Increased levels of reactive oxygen species have been seen in human tumors and have been implicated in mitogenic growth, raising the possibility that Nox enzymes might be overexpressed or activated in colon cancer. When overexpressed in fibroblast, Nox1 produces low levels of superoxide and also manifested cell-transforming activities (Suh et al, 1999; Cheng and Lambeth, 2004). In earlier studies, we found that Nox1 mRNA is overexpressed in pooled samples of colon cancer compared with normal colon tissue. These results suggests that aberrant expression of Nox1 in colon may contribute to the development of colon cancer. Our current goal is to (i) examine Nox1 expression in normal human colonic epithelium as well as colon carcinoma cell lines, (ii) determine if Nox 1 protein is differentially expressed in colon cancer, and (iii) elucidate cell signaling pathways in which Nox1 is involved.

Teaching Philosophy

The purpose of education is simple: to prepare students for survival in the real world.  As an educator, my goal is to ensure that students are equipped with the skills that they will need to survive.  These skills include the ability to reason and the ability to apply knowledge rather than just store it up; to use discernment and critical thinking skills to assess problems.  Furthermore, it requires interpersonal skills and the ability to work collaboratively with others.  It also includes recognizing one’s value as a person and as a member of society.

I believe that the role of a teacher is that of a facilitator.  Students should take an active part, rather than a backseat, in their learning.  Students are not empty vessels in which one pours in knowledge.  Students have to desire that knowledge and have the proficiency to go and seek it.  Hence it is important for students to develop skills that will ensure they can assess their own learning.  Students should be confident in contributing their knowledge to the classroom and realize that they can be both teacher and student.

Education is not about classroom knowledge; it is about real-world survival skills.  Learning is a skill.  To teach students to survive, one must teach them to learn.

 

Recent Publications

Laurent, E., McCoy, J.W. 3rd, Macina, R.A., Liu, W., Cheng, G., Robine, S., Papkoff, J., Lambeth, J.D.  (2008) Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras. Int J Cancer.123(1):100-7. PMCID: PMC3774003

Laurent, E., Mitchell, D.L., Estrov, Z., Lowery, M., Tucker, S.L., Talpaz, M., Kurzrock, R. (2003) Impact of p210Bcr-Abl on ultraviolet C wavelength-induced DNA damage and repair. Clinical Cancer Research 9: 3722-3730.

Laurent, E., Talpaz, M., Kantarjian, H., Kurzrock, R. (2001) The BCR gene and Philadelphia chromosome-positive leukemogenesis. Cancer Research 61: 2343-2355 (Review).

Laurent, E., Talpaz, M., Wetzler, M., Kurzrock, R.. (2000) Cytoplasmic and nuclear localization of the 130kD and 160kD Ber proteins. Leukemia 14:1892-1897.

 

Valencia College
Osceola Campus (MC 6-8)
1800 Denn John Lane
Kissimmee, FL 34744
Telephone: 407.582.5838
Email: elaurent1@valenciacollege.edu


Emory University School of Medicine
Department of Physiology
Atlanta, GA 30322-3110
(404) 727-7410 Office ~ (404) 727-2648 FAX

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