Gretchen Neigh, Ph.D.

Assistant Professor

Department of Physiology, Emory University School of Medicine


Education

B.A., Biology, Washington and Jefferson College, Washington, PA, 1998
Ph.D., Neuroscience, Ohio State University, Columbus, OH, 2004
FIRST Postdoctoral Fellow, Department of Psychiatry, Emory University School of Medicine, 2005-2007


Research Statement

Since joining the FIRST program in September 2005, I've had several accomplishments. I was awarded an individual Ruth L. Kirschstein National Research Service Award from the National Institute of Health in February 2006 to fund my research on the effects of stress on cerebral vasculature. In addition, I received an International Neuroendocrine Travel Award to travel to the International Congress on Neuroendocrinology to present a poster entitled, "Cardiac arrest and cardiopulmonary resuscitation increases CRF R1 receptor binding," in June of 2006. I also published a focus article with my research mentor in the journal "Trends in Endocrinology and Metabolism," which is entitled, "Reduced glucocorticoid receptors: consequence or cause of depression?" In addition, I submitted two scientific abstracts and two teaching abstracts for presentation at the Society for Neuroscience Conference which will take place in October 2006.

 

Grant Support

Current Support
Agency: NIH/NIMH
Project Number: 1K18MH105098-01
Title: GLUT 1 POLYMORPHISM DECREASES INCIDENCE OF DEPRESSION AND PTSD AFTER TRAUMA
Project Period: September 15, 2014 - August 31, 2015

Past Support
Agency:
NIH/NIMH
Project Number: 5R21MH091321-02
Title: CHRONIC STRESS EFFECTS ON CEREBRAL GLUCOSE TRANSPORTERS: ADOLESCENT SPECIFIC?
Project Period: July 1, 2010 - March 31, 2013

 

Recent Publications

Nemeth, C.L., Reddy, R., Mandakh, B., Bailey, J., Neigh, G.N. (2014)  Microglial activation occurs in the absence of anxiety-like behavior following microembolic stroke in female, but not male, rats. J Neuroinflammation. 11:174. PMCID: PMC4232723

Nemeth, C.L., Glasper, E.R., Harrell, C.S., Malviya, S.A., Otis, J.S., Neigh, G.N. (2014) Meloxicam Blocks Neuroinflammation, but Not Depressive-Like Behaviors, in HIV-1 Transgenic Female Rats. PLoS One. 9:e108399. PMCID: PMC4182732

Burgado, J., Harrell, C.S., Eacret, D., Reddy, R., Barnum, C.J., Tansey, M.G., Miller, A.H., Wang, H., Neigh, G.N. (23014) Two weeks of predatory stress induces anxiety-like behavior with co-morbid depressive-like behavior in adult male mice. Behav Brain Res. 275C:120-125.

Nemeth, C.L., Haroon, E., Neigh, G.N. (2014) Heartsick: psychiatric and inflammatory implications of cerebromicrovascular disease. Int J Geriatr Psychiatry. 29:577-85.

Bourke, C.H., Glasper, E.R., Neigh, G.N. (2014) SSRI or CRF antagonism partially ameliorate depressive-like behavior after adolescent social defeat. Behav Brain Res. 270:295-9.

Nemeth, C.L., Gutman, D.A., Majeed, W., Keilholz, S.D., Neigh, G.N. (2014) Microembolism induces anhedonia but no detectable changes in white matter integrity in aged rats. PLoS One. 9(5):e96624. PMCID: PMC4014537

Panagiotakopoulos, L., Neigh, G.N. (2014) Development of the HPA axis: where and when do sex differences manifest? Front Neuroendocrinol. 35:285-302.

Kelly, S.D., Harrell, C.S., Neigh, G.N. (2014) Chronic stress modulates regional cerebral glucose transporter expression in an age-specific and sexually-dimorphic manner. Physiol Behav. 126:39-49. PMCID: PMC3962826

Sawyer, N.T., Papale, L.A., Eliason, J., Neigh, G.N., Escayg, A. (2014) Scn8a voltage-gated sodium channel mutation alters seizure and anxiety responses to acute stress. Psychoneuroendocrinology. 39:225-36. PMCID: PMC3989103

Greenlee, M.M., Mitzelfelt, J.D., Yu, L., Yue, Q., Duke, B.J., Harrell, C.S., Neigh, G.N., Eaton, D.C. (2013) Estradiol activates epithelial sodium channels in rat alveolar cells through the G protein-coupled estrogen receptor. Am J Physiol Lung Cell Mol Physiol. 305:L878-89. PMCID: PMC3882529

Bourke, C.H., Stowe, Z.N., Neigh, G.N., Olson, D.E., Owens, M.J.  (2013) Prenatal exposure to escitalopram and/or stress in rats produces limited effects on endocrine, behavioral, or gene expression measures in adult male rats. Neurotoxicol Teratol. 39:100-9. PMCID: PMC3795959

Nemeth, C.L., Harrell, C.S., Beck, K.D., Neigh, G.N. (2013) Not all depression is created equal: sex interacts with disease to precipitate depression. Biol Sex Differ. 4:8. PMCID: PMC3639119

Harrell, C.S., Hardy, E., Boss-Williams, K., Weiss, J.M., Neigh, G.N. (2013)  Sex and lineage interact to predict behavioral effects of chronic adolescent stress in rats. Behav Brain Res. 248:57-61.

Nemeth, C.L., Shurte, M.S., McTigue, D.M., Nemeroff, C.B., Neigh, G.N. (2012) Microembolism infarcts lead to delayed changes in affective-like behaviors followed by spatial memory impairment.  Behav Brain Res. 234:259-66.

Bourke, C.H., Raees, M.Q., Malviya, S., Bradburn, C.A., Binder, E.B., Neigh, G.N. (2012) Glucocorticoid sensitizers Bag1 and Ppid are regulated by adolescent stress in a sex-dependent manner.  Psychoneuroendocrinology. 38:84-93.  PMCID: PMC3443296

Bourke, C.H., Harrell, C.S., Neigh, G.N. (2012) Stress-induced sex differences: Adaptations mediated by the glucocorticoid receptor.  Horm Behav. 62:210-8. PMCID: PMC3384757

Barnum, C.J., Pace, T.W., Hu, F., Neigh, G.N., Tansey, M.G. (2012) Psychological stress in adolescent and adult mice increases neuroinflammation and attenuates the response to LPS challenge.  J Neuroinflammation. 9:9.  PMCID: PMC3283491

Bourke, C.H., Neigh, G.N. (2012) Exposure to repeated maternal aggression induces depressive-like behavior and increases startle in adult female rats.  Behav Brain Res. 227:270-5. PMCID: PMC3242888

Bourke, C.H., Neigh, G.N. (2011) Behavioral effects of chronic adolescent stress are sustained and sexually dimorphic. Horm Behav. 60:112-20. PMCID: PMC3112263

Neigh, G.N., Owens, M.J., Taylor, W.R. and Nemeroff, C.B. (2010) Changes in vascular area fraction of the hippocampus and amygdala are induced by prenatal dexamethasone and/or adult stress. J. Cereb Blood Flow Metab. 30:1100-4. PMCID: PMC2949211

Neigh, G.N., Karelina, K., Glasper, E.R., Bowers, S.L., Zhang, N., Popovich, P.G., DeVries, A.C. (2009) Anxiety after cardiac arrest/cardiopulmonary resuscitation: exacerbated by stress and prevented by minocycline. Stroke. 40(11):3601-7. PMCID: PMC2805193

Neigh, G.N., Gillespie, C.F., Nemeroff, C.B. (2009) The neurobiological toll of child abuse and neglect. Trauma Violence Abuse. 10:389-410.

 

Emory University School of Medicine
Department of Physiology
605E Whitehead Biomedical Research Bldg.

Atlanta, GA 30322
Tel: 404.727.9022
Fax: 404.727.2648
Email: gretchen.neigh@emory.edu


Emory University School of Medicine
Department of Physiology
Atlanta, GA 30322-3110
(404) 727-7410 Office ~ (404) 727-2648 FAX

For questions or comments, contact the webmaster at FIRST@emory.edu.