Gretchen Neigh, Ph.D.

Assistant Professor

Department of Physiology, Emory University School of Medicine


Education

B.A., Biology, Washington and Jefferson College, Washington, PA, 1998
Ph.D., Neuroscience, Ohio State University, Columbus, OH, 2004
FIRST Postdoctoral Fellow, Department of Psychiatry, Emory University School of Medicine, 2005-2007


Research Statement

Since joining the FIRST program in September 2005, I've had several accomplishments. I was awarded an individual Ruth L. Kirschstein National Research Service Award from the National Institute of Health in February 2006 to fund my research on the effects of stress on cerebral vasculature. In addition, I received an International Neuroendocrine Travel Award to travel to the International Congress on Neuroendocrinology to present a poster entitled, "Cardiac arrest and cardiopulmonary resuscitation increases CRF R1 receptor binding," in June of 2006. I also published a focus article with my research mentor in the journal "Trends in Endocrinology and Metabolism," which is entitled, "Reduced glucocorticoid receptors: consequence or cause of depression?" In addition, I submitted two scientific abstracts and two teaching abstracts for presentation at the Society for Neuroscience Conference which will take place in October 2006.

 

Grant Support

Agency: NIH/NIMH
Project Number: 5R21MH091321-02
Title: CHRONIC STRESS EFFECTS ON CEREBRAL GLUCOSE TRANSPORTERS: ADOLESCENT SPECIFIC?
Project Period: July 1, 2010 - March 31, 2013

 

Recent Publications

Sawyer, N.T., Papale, L.A., Eliason, J., Neigh, G.N., Escayg, A. (2014) Scn8a voltage-gated sodium channel mutation alters seizure and anxiety responses to acute stress. Psychoneuroendocrinology. 39:225-36.

Greenlee, M.M., Mitzelfelt, J.D., Yu, L., Yue, Q., Duke, B.J., Harrell, C.S., Neigh, G.N., Eaton, D.C. (2013) Estradiol activates epithelial sodium channels in rat alveolar cells through the G protein-coupled estrogen receptor. Am J Physiol Lung Cell Mol Physiol.; 305(11):L878-89.

Bourke, C.H., Stowe, Z.N., Neigh, G.N., Olson, D.E., Owens, M.J.  (2013) Prenatal exposure to escitalopram and/or stress in rats produces limited effects on endocrine, behavioral, or gene expression measures in adult male rats. Neurotoxicol Teratol.; 39:100-9. PMCID: PMC3795959

Nemeth, C.L., Harrell, C.S., Beck, K.D., Neigh, G.N. (2013) Not all depression is created equal: sex interacts with disease to precipitate depression. Biol Sex Differ.; 4(1):8. PMCID: PMC3639119

Harrell, C.S., Hardy, E., Boss-Williams, K., Weiss, J.M., Neigh, G.N. (2013)  Sex and lineage interact to predict behavioral effects of chronic adolescent stress in rats. Behav Brain Res.; 248:57-61.

Nemeth, C.L., Shurte, M.S., McTigue, D.M., Nemeroff, C.B., Neigh, G.N. (2012) Microembolism infarcts lead to delayed changes in affective-like behaviors followed by spatial memory impairment.  Behav Brain Res. 234(2):259-66.

Bourke, C.H., Raees, M.Q., Malviya, S., Bradburn, C.A., Binder, E.B., Neigh, G.N. (2012) Glucocorticoid sensitizers Bag1 and Ppid are regulated by adolescent stress in a sex-dependent manner.  Psychoneuroendocrinology.38(1):84-93.  PMCID: PMC3443296

Bourke, C.H., Harrell, C.S., Neigh, G.N. (2012) Stress-induced sex differences: Adaptations mediated by the glucocorticoid receptor.  Horm Behav. 2012 Mar 3. [Epub ahead of print] PMCID: PMC3384757

Barnum, C.J., Pace, T.W., Hu, F., Neigh, G.N., Tansey, M.G. (2012) Psychological stress in adolescent and adult mice increases neuroinflammation and attenuates the response to LPS challenge.  J Neuroinflammation. 9:9.  PMCID: PMC3283491

Bourke, C.H., Neigh, G.N. (2012) Exposure to repeated maternal aggression induces depressive-like behavior and increases startle in adult female rats.  Behav Brain Res. 227(1):270-5.

Bourke, C.H., Neigh, G.N. (2011) Behavioral effects of chronic adolescent stress are sustained and sexually dimorphic. Horm Behav. 60(1):112-20. PMCID: PMC3112263

Neigh, G.N., Owens, M.J., Taylor, W.R. and Nemeroff, C.B. (2010) Changes in vascular area fraction of the hippocampus and amygdala are induced by prenatal dexamethasone and/or adult stress. J. Cereb Blood Flow Metab. 30(6):1100-4. PMCID: PMC2949211

Neigh, G.N., Karelina, K., Glasper, E.R., Bowers, S.L., Zhang, N., Popovich, P.G., DeVries, A.C. (2009) Anxiety after cardiac arrest/cardiopulmonary resuscitation: exacerbated by stress and prevented by minocycline. Stroke. 2009 Nov;40(11):3601-7.

Neigh, G.N., Gillespie, C.F., Nemeroff, C.B. (2009) The neurobiological toll of child abuse and neglect. Trauma Violence Abuse. 10(4):389-410. PMCID: PMC2805193

Neigh, G.N., Karelina, K., Zhang, N., Glasper, E.R., Owens, M.J., Plotsky, P.M., Nemeroff, C.B., DeVries, A.C.  (2009) Cardiac arrest and cardiopulmonary resuscitation dysregulates the hypothalamic-pituitary-adrenal axis. J Cereb Blood Flow Metab. 29:1673-1682.

Neigh, G.N., Nemeroff, C.B.  (in press) Neuroendocrinology.  In: Gelder, Med. New Oxford Textbook of Psychiatry.  2nd ed. Oxford University Press; 2009.

Devries, A.C., Craft, T.K., Glasper, E.R., Neigh, G.N., Alexander, J.K. (2007) 2006 Curt P. Richter award winner: Social influences on stress responses and health. Psychoneuroendocrinology. 32(6):587-603.

Nemeroff, C.B., Neigh, G.N. (2006) Response to rubin and carroll and van den eede et Al. Trends Endocrinol Metab. 17(10):387.

Neigh, G.N. and Nemeroff, C.B.  (2006) Reduced glucocorticoid receptors: consequence or cause of depression? Trends Endocrinol Metab. 17(4):124-125.

Neigh, G.N., Glasper, E., Bilbo, S.D., Traystman, R.J., DeVries, A.C. (2005) Cardiac arrest/cardiopulmonary resuscitation augments cell-mediated immune function and transiently suppresses humoral immune function. Journal of Cerebral Blood Flow and Metabolism.

Pyter, L.M., Neigh, G.N., and Nelson, R.J. (2005) Social environment modulates photoperiodic immune and reproductive responses in adult male white-footed mice (Peromyscus leucopus). American Journal of Physiology: Comparative & Integrative, 288:R891-6.

Neigh, G.N., Samulsson, A., Bowers, S.L., Nelson, R.J. (2005) 3-Aminobenzamide prevents restraint-evoked immunosuppression. Brain, Behavior and Immunity, 19:351-356.

Neigh, G.N., Bowers, S.L., Korman, B., Nelson, R.J. (2005) Housing environment alters cell-mediated immune function and corticosterone concentrations. Animal Welfare, 14:000-000.

Gatien, M.L., Hotchkiss, A.K., Neigh, G.N., Dhabhar, F., Nelson, R.J. (2004) Immune and stress responses in C57Bl/6 and C3H mouse strains following photoperiod manipulation. Neuroendocrinology Letters, 25:267-272.

Hotchkiss, A.K., Pyter, L.M., Neigh, G.N., Nelson, R.J. (2004) Nycthemeral differences in response to restraint stress in CD-1 and C57BL/6J mice. Physiology and Behavior, 80:441- 447.

Neigh, G.N., Arnold, H.M., Rabenstein, R.L., Sarter, M., Bruno, J.P. (2004) Neuronal activity in the nucleus accumbens is necessary for performance-related increases in cortical acetylcholine release. Neuroscience, 123:635-645.

Neigh, G.N., Bilbo, S.D., Hotchkiss, A.K., Nelson, R.J. (2004) Exogenous pyruvate prevents stress-evoked suppression of mitogen-stimulated proliferation. Brain, Behavior and Immunity, 18:425-433.

Neigh, G.N., Bowers, S.L., Pyter, L.M., Gatien, M.L., Nelson, R.J. (2004) Pyruvate prevents restraint-induced immunosuppression via alterations in glucocorticoid responses. Endocrinology, 145:4309-4319

Neigh, G.N., Glasper, E., Kofler, J., Traystman, R.J., Mervis, R., Bachstatter, A., DeVries, A.C. (2004) Cardiac arrest/cardiopulmonary resuscitation selectively alters formation of spatial memory and abates dendritic spines of CA1 pyramidal cells. European Journal of Neuroscience, 20:1865-1872.

Neigh, G.N., Kofler, J., Meyers, J.L., Traystman, R.J., Bergdall, V., La Perle, K., DeVries, A.C. (2004) Cardiac arrest/cardiopulmonary resuscitation increases anxiety-like behavior and decreases social interaction. Journal of Cerebral Blood Flow and Metabolism, 24:372-382.

 

Emory University School of Medicine
Department of Physiology
605E Whitehead Biomedical Research Bldg.

Atlanta, GA 30322
Tel: 404.727.9022
Fax: 404.727.2648
Email: gretchen.neigh@emory.edu


Emory University School of Medicine
Department of Physiology
Atlanta, GA 30322-3110
(404) 727-7410 Office ~ (404) 727-2648 FAX

For questions or comments, contact the webmaster at FIRST@emory.edu.