Juana Mendenhall, Ph.D.

Assistant Professor

Department of Chemistry, Morehouse College


 

Education

B.S., Chemistry, North Carolina A & T State University, Greensboro, NC, 1998
Ph.D., Chemistry, Clark Atlanta University, Atlanta, GA, 2006
Postdoctoral Fellow, Food Science, Cornell University, Ithaca, NY, 2006-2007
FIRST Postdoctoral Fellow, Department of Biomedical Engineering, Emory/Georgia Institute of Technology, 2008-2009


Research Statement

With 12.1 percent of the U.S. population suffering from osteoarthritis and more than 13.5 million people experiencing daily joint pain, not only is tissue repair a prominent medical issue, but it also presents a problem with no simple solution. In an osteoarthritic (OA) knee the joint fluid (synovial fluid) may deplete and not provide the proper support as a healthy knee. Osteochondral (articular cartilage and subchondral bone) defects account for a majority of local knee defects which may result in osteoarthritis over a period of time. On the molecular level, extra cellular matrix components such as type II collagen, type IX collagen, aggregan denature in addition to subchondral bone all effecting the mechanical integrity of the knee joint. With this in mind, my current research interests are focused on osteochondral tissue engineering tailored towards OA pathology. More specifically, my research thrusts are aimed at constructing novel thermoresponsive antioxidant injectable hybrid gels that will replace existing viscosupplementation treatment options and subsequently reduce reactive oxygen species by blocking the inflammatory response affiliated with OA. My research interest incorporate three foci to engineer the articular cartilage-subchondral bone interface: i) design and preparation of thermo-sensitive hydrogels comprised of an antioxidant and hyluaronic acid component with functional end groups for immobilizing proteins; ii) the investigation the chondrogenic and osteogenic migration throughout 3D sol-gels under normal and hypoxic static conditions; and iii) the analysis of reactive oxygen species as a result of PVCL-a-tocopherol acrylate antioxidant hybrid copolymers sol-gels interaction at the cartilage-bone interface. Additionally, I am investigating the extra cellular matrix of the cartilage-bone interface using Atomic Force Microscopy to further understand the nanoscale phenomenonan of type II collagen degradation.

 

Publications

Gordon, K., Sannigraphi, B., McGeady, P., Wang, X., Mendenhall, J., Khan, I. (2009) Synthesis of Optically Active Helical Poly(2-methoxystyrene). Enhancement of HeLa and Osteoblast Cell Growth on Optically Active Helical Poly (2-methoxystyrene) Surfaces. J Biomater Sci Polym Ed. 20:2055-72.

Chen, H., Abraham, S., Mendenhall, J., Delamarre, S., Smith, K., Kim, I., Batt, C. (2008) Encapsulation of single small gold nanoparticles by diblock copolymers. ChemPhysChem. 9:388-392.

Mendenhall, J., Hinestroza, J., Frey, M. Babalola, O., Bonassar, L., Batt, C. (2007) Piezoelectric Poly(3-hydroxybutryate)-Poly(lactic acid) Three Dimensional Scaffolds for Bone Tissue Engineering. MRS Symposium Proceedings series. Nanoscale Phenomena in Functional Materials by Scanning Probe Microscopy. www.mrs.org/publications_library Volume 1025E. 

McDevitt, M. Chattopadhyay, D., Jaggi, J., Zanzonico, R., Villa, C., Rey, D., Mendenhall, J., Batt, C., Njardarson, J., Scheinberg, D. (2007) PET imaging of soluble yttrium-86-labeled carbon nanotubes in mice. Plos One. 2:e907. PMCID: PMC1975469

 

Morehouse College
Department of Chemistry
218 Merrill Hall
830 Westview Drive, S.W.
Atlanta, GA 30314-3773
Tel: 404.681.2800 x 2286
Fax: 404.614.3782
Email: jmendenhall@morehouse.edu


Emory University School of Medicine
Department of Physiology
Atlanta, GA 30322-3110
(404) 727-7410 Office ~ (404) 727-2648 FAX

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